Pre-Exposure Prophylaxis


How can we leverage biomedical prevention to promote liberation and sexual health? 

The advent of pre-exposure prophylaxis (PrEP), the first biomedical prevention strategy, represents a tremendous opportunity to reboot our approach to HIV prevention messages and intervention. At HART, our work focuses on leveraging PrEP to both pioneer new prevention strategies and approaches, and to draw attention to the need for new paradigms and narratives that emphasize health and sex positivity, as opposed  as  to risk and fear of disease. We work with Departments of Health, community-based organizations, and clinical settings to develop and evaluate new programs.




SPARK:  Intervention to Enhance PrEP Uptake and Adherence in a Community Setting  (R01AA022067; Golub, PI)

SPARK is a collaboration between HART and Callen-Lorde Community Health Center (CLCHC), the largest LGBT health center in New York City. SPARK was the first PrEP demonstration project in NYC and was designed to develop a protocol for PrEP to be integrated into regular care at a community-based health center. In addition, SPARK developed and tested two brief behavioral interventions, one focused on sexual health that assists patients in deciding whether or not to take PrEP, and the other designed to support adherence among patients who choose PrEP. This intervention is the first to demonstrate efficacy in improving PrEP adherence among patients. You can learn more about the SPARK interventions here. 

PrEPARE: Impact of PrEP Messaging on Comprehension, Acceptability, and Risk (R01MH095565; Golub, PI)

PrEPARE combined theories and approaches from social psychology, health psychology, decision-sciences, and communications to test the impact of different messaging characteristics on patients' comprehension, interest, and motivations. We recruited over 500 gay/bisexual men and transgender women to evaluate PrEP messaging strategies and explore the association between PrEP-related attitudes and behavior.

Products and Findings

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Select Publications

Lelutiu-Weinberger, C. & Golub, S.A. (2016). Enhancing PrEP Access for Black and Latino men who have sex with men. Journal of Acquired Immune Deficiency Syndrome, 73(5), 547-555.

Golub, S.A., Gamarel, K.E., & Lelutiu-Weinberger, C. (2016). The importance of sexual history taking for PrEP comprehension among young people of color. AIDS and Behavior, 1-10.